HORDB

ID: hor006736
Uniprot ID: P47744
Protein name: Glycoprotein hormones alpha chain
Gene name: cga
Organism: Fundulus heteroclitus (Killifish) (Mummichog)
Family: Glycoprotein hormones subunit alpha family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Fundulus (genus), Fundulidae (family), Cyprinodontoidei (suborder), Cyprinodontiformes (order), Atherinomorphae (superorder), Ovalentaria , Percomorphaceae , Euacanthomorphacea , Acanthomorphata , Ctenosquamata , Eurypterygia , Neoteleostei , Euteleosteomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity; GO:0016913 follicle-stimulating hormone activity
GO BP: GO:0007186 G protein-coupled receptor signaling pathway; GO:0010469 regulation of signaling receptor activity; GO:0010893 positive regulation of steroid biosynthetic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0016914 follicle-stimulating hormone complex

Sequence: HPNFDSSSMACGECSLGLNRLFSRDRPLYQCMGCCFSRAYPTPQTAIQTMAIPKNITSEAKCCVAKHSYETKVDDITVRNHTECHCSTCYYHKLI
Length: 95(31-125)
Propeptide: MVSAVTTMGCMKAAGVSLLLLYFLLNAADSHPNFDSSSMACGECSLGLNRLFSRDRPLYQCMGCCFSRAYPTPQTAIQTMAIPKNITSEAKCCVAKHSYETKVDDITVRNHTECHCSTCYYHKLI
Signal peptide: MVSAVTTMGCMKAAGVSLLLLYFLLNAADS
Modification: NA
Glycosylation: T55 N-linked (GlcNAc...) asparagine;T80 N-linked (GlcNAc...) asparagine
Mutagenesis: NA

Function: Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006736_AF2.pdb

hor006736_ESM.pdb

Mass:	1240713	Formula:	C457H714N132O141S13
Absent amino acids:	W	Common amino acids:	CS
pI:	7.9	Basic residues:	15
Polar residues:	39	Hydrophobic residues:	22
Hydrophobicity:	-36.84	Boman Index:	-17902
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.53
Instability Index:	5477.05	Extinction Coefficient cystines:	8075
Absorbance 280nm:	85.9